Program
At a Glance
Chew Sek-Jin Award Lecture
【Session Room 1】14-Sep 11:20-12:20
- Chairs:
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Christine Wildsoet
-
-
Kyoko Ohno-Matsui
- Awardee:
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Professor Earl L. Smith III
Dean, College of Optometry, University of Houston
- Title of Lecture:
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Do low ambient lighting levels promote the development of myopia in primates?
A variety of observations suggest that low ambient lighting levels could put the eye at risk for developing myopia. We investigated the effects of low ambient lighting on normal refractive development and deprivation- and defocus-induced ametropias in infant monkeys. Specifically, 29 rhesus monkeys were housed under dim ambient lighting (5-36 lux) maintained on a 12 hour lights-on/12 lights-off cycle from 24 to 154 days of age. During the dim light (DL) period, animals were allowed unrestricted vision (n=7) or were reared wearing monocular diffusers (n=7), or either monocular -3D (n=7) or +3D spectacle lenses (n=8). Comparison data were obtained from age-matched control animals that were subjected to the same rearing strategies, but housed under typical laboratory lighting levels (~350 lux). The DL regimen resulted in more variable, but relative hyperopic, ametropias in animals reared with unrestricted vision. DL did not alter the course of form-deprivation myopia; however, it did reduce the likelihood that animals reared with either -3D or +3D of imposed anisometropia would exhibit compensating anisometropic growth. Data from both the treated and fellow-control eyes of lens-reared monkeys suggested that DL diminished the normal response to myopic defocus. Thus, DL appears to reduce the efficiency of emmetropization and, in the case of lens-treated monkeys, the ability of myopic defocus to slow ocular growth. Thus, DL can increase the risk of myopia.
ZEISS Young Investigator Award in Myopia Research 2019 &
Josh Wallman Memorial Lecture
【Session Room 1】12-Sep 10:45-11:45
- Chairs:
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Christine Wildsoet
-
-
Kyoko Ohno-Matsui
- Awardee:
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Dr. Virginie J.M. Verhoeven
Erasmus Medical Center
- Title of Lecture:
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A Decade of Human Myopia Genetics Research:
Big data, Big questions
The knowledge on the genetic background of refractive error and myopia has expanded dramatically in the past few years. To date, almost 200 genetic loci have been identified for refractive error and myopia, and risk variants mostly carry low risk but are highly prevalent in the general population. Several genes for secondary syndromic myopia overlap with those for common myopia. Polygenic risk scores show overrepresentation of high myopia in the higher deciles of risk. Annotated genes have a wide variety of functions, and all retinal layers appear to be sites of expression. The current genetic findings offer a world of new molecules involved in myopiagenesis. As the missing heritability is still large, further genetic advances including large-scale, in-depth genetic studies using complementary big data analytics, consideration of gene-environment effects by thorough measurement of environmental exposures, and focus on subgroups with extreme phenotypes and high familial occurrence are needed. Functional characterization of associated variants is simultaneously needed to bridge the knowledge gap between sequence variance and consequence for eye growth.
Symposia
Symposium 1
●National Myopia Prevention and Control Policies - An Update
- Chairs:
- Ian Morgan
- (Australian National University)
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- Kyoko Ohno-Matsui
- (Tokyo Medical and Dental University)
Introduction. What are the options?
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- Ian Morgan
- (Australian National University)
Myopia prevention and control in Taiwan
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- Pei-Chang Wu
- (Kaohsiung Chang Gung Memorial Hospital)
Myopia prevention and control in Singapore
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- Seang-Mei Saw
- (National University of Singapore)
Progress towards defining a myopia prevention and control strategy for mainland China
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- Mingguang He
- (University of Melbourne)
The Strategy for Myopia Control and Prevention in the UK
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- Nicola Logan
- (Aston University)
Updates of treatment for Myopic Medical/Surgical Complications
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- Yasushi Ikuno
- (Ikuno Eye Center)
Symposium 2
●International Myopia Institute: the possibilities and the probabilities
- Moderators:
- Serge Resnikoff
- (Brien Holden Vision Institute)
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- Earl L. Smith III
- (University of Houston)
- Organiser:
- Monica Jong
- (Brien Holden Vision Institute)
- Panelists:
- Daniel I. Flitcroft
- (University Coll. Dublin and Dublin Inst. of Technology)
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- David Troilo
- (SUNY Coll. of Optometry, State University of New York)
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- Christine F. Wildsoet
- (UC Berkeley)
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- Nicola S. Logan
- (Aston University)
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- Caroline C. W. Klaver
- (Radboud University Medical Center)
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- Kate L. Gifford
- (Queensland University of Technology)
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- Jacinto Santodomingo-Rubido
- (Menicon Company Limited)
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- Lyle Gray
- (Glasgow Caledonian University)
Paper
Oral 1【Session Room 1】12-Sep 8:15-9:03
●Prevalence, Progression and Biometric Changes
- Chair:
- James Loughman
- (Centre for Eye Research Ireland,
Technological University Dublin)
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- Nicola Logan
- (Aston University)
Application of Big-Data for Epidemiological Studies of Refractive Error
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- Michael Moore
-
Potential Value of Centile Analysis in Eye Growth and Refractive Development
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- Daniel I. Flitcroft
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The Progression of Myopia before the Age of 25 Years: The DREAM Study
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- Willem Tideman
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Progression and Longitudinal Biometric Changes in Highly Myopic Eyes
-
- Mingguang He
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Oral 2【Session Room 1】12-Sep 9:35-10:35
●Genetics
- Chair:
- Chris Hammond
- (King’s College London)
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- Milly Tedja
- (Ophthalmology and Epidemiology,
Erasmus Medical Centre)
Genetic and Parental Factors of Myopia
-
- Calvin C. P. Pang
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Genetic Study of 542,934 Subjects Identifies Novel Genes and Genetic Mechanisms Predisposing to Refractive Error and Myopia
-
- Christopher Hammond
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Improving Prediction of Myopia using Information on Genetic Risk Factors
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- Pirro Hysi
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Pathway-Specific Genetic Risk Scores Associated with High Myopia
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- Milly S. Tedja
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Analysis of Genetic Networks Regulating Refractive Eye Development in Collaborative Cross Mice Reveals New Genes and Pathways Underlying Human Myopia
-
- Andrei V. Tkatchenko
-
Oral 3【Session Room 1】12-Sep 15:28-17:16
●Environmental Risk Factors
- Chair:
- Seang-Mei Saw
- (Singapore Eye Research Institute)
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- Pei-Chang Wu
- (Kaohsiung Chang Gung Memorial Hospital)
A Systematic Review: The Role of Time Exposed to Outdoor Light for Myopia Prevalence and Progression
-
- Leila S. Eppenberger
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Outdoor Play, Playgrounds, and Myopia in Children
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- Clair Enthoven
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Habitual Indoor and Outdoor Activity of Myopic and Non-Myopic University Students in the United States and Norway
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- Elise N. Harb
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Comparison of Outdoor Exposure and Nearwork between Children with and without Parents with Myopia by Using Clouclip
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- Weizhong Lan
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Outdoor Jogging and Myopia Progression in School Children from Rural Beijing: The Beijing Children Eye Study
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- Yin Guo
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Myopia and Risk Factor Exposures within Academically-streamed Schools
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- Amanda N. French
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Refractive Error Change among Schoolchildren with 1-Year Tablet Computer Use as Educational Tool in School
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- Jung Lo
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Recent, but Not Past, Vitamin D Concentrations are Associated with Myopia in Young Adulthood
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- Gareth N. Lingham
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Sleep Duration and Myopia Progression in a Four-year Follow-up of Chinese Children: The Anyang Childhood Eye Study
-
- Shi-Fei Wei
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Oral 4-1【Session Room 1】13-Sep 8:35-9:50
●Animal Models and Basic Research I
- Chair:
- Frank Schaeffel
- (University of Tübingen)
-
- Chi-Ho To
- (The Hong Kong Polytechnic University)
Special Lecture: Genetically Modified Animal Models of Myopia
-
- Terri Young
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Reviewing Lens-induced Myopia in C57BL/6 Mice
-
- Beerend Winkelman
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Differential Wavelength Cues are Essential for Emmetropization in Tree Shrews
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- Timothy J. Gawne
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Effects of Myopic-astigmatic Development on Retinal Functions in Chicken
-
- Sonal A. Vyas
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The Impact of Exposure to Multiple Episodes of Defocus on Chick Eye Growth
-
- Pauline Kang
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Amacrine Cells Expressing nNOS are Sensitive to the Sign of Defocus in the Mammalian Retina
-
- Sally A. McFadden
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Oral 4-2【Session Room 1】13-Sep 9:50-11:14
●Animal Models and Basic Research II
- Chair:
- Timothy Gawne
- (University of Alabama at Birmingham)
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- Alexandra Benavente-Perez
- (SUNY College of Optometry)
The Mechanism Study of Dopamine D2 Receptor Involving the Flickering Light Induced Myopia of Guinea Pigs
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- Shunmei Ji
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Low Dose Atropine Does Not Influence Dopamine Release in Chickens
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- Kate Thomson
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Atropine Distribution in the Chick Eye: Analysis using Mass Spectrometry and Immunoassays
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- Muthana H. Noori
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Scleral Hif-1α Knock-down Shifted Refraction toward Hyperopia in Normal Environment but Suppressed Form-deprivation Myopia (FDM) Development in Mice
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- Xiangtian Zhou
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Changes in Choroidal Thickness and Choroidal Blood Perfusion in Guinea Pig Myopia
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- Guoyun Zhang
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Decreased Stiffness and Increased Permeability in Sclera of Myopic Mice
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- Dillon M. Brown
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Two Quantitative High-frequency Ultrasound Methods to Assess Microstructural Changes in Guinea Pig Sclera
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- Jonathan Mamou
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Oral 5【Session Room 1】13-Sep 11:14 -12:02
●Accommodation/Binocular Vision
- Chair:
- Lisa Ostrin
- (University of Houston College of Optometry)
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- Sandra Wagner
- (Eberhard Karls University Tuebingen)
Comparison of Different Techniques to Assess the Near Accommodation Responses
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- Ting Wang
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Emmetropes and Myopes Differ Little in Their Accommodation Dynamics but Strongly in Their Ciliary Muscle Morphology
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- Sandra Wagner
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Early Warning Effect of Accommodative Facility in the Occurrence of Myopia in Adolescents
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- Xiaoyan Yang
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Comparison of Binocular Imbalance in Emmetropic and Myopic Volunteers under a Non-immersive Virtual Reality Platform
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- Jin Zeng
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Oral 6【Session Room 1】13-Sep 16:05-17:41
●Spectacles and Ortho K
- Chair:
- Toshifumi Mihashi
- (University of Tsukuba)
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- Sally McFadden
- (University of Newcastle)
The Effect of Orthokeratology Compression Factor on Ocular Higher-order Aberrations
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- Jason K. Lau
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Clinical Observation of Effect of Long-term Overnight Wearing of Orthokeratology Lenses on Myopia Progression and Ocular Safety in Adolescents
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- Yin Yang
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Comparison of Myopia Progression between Children Wearing Three Types of Orthokeratology (Ortho-K) Lenses and Children Wearing Single Vision Glasses
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- Yo Nakamura
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Comparisons of the Myopia Control Effects of Standard Design and Toric Design Orthokeratology Lenses
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- Zhao Chen
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Influence of Change to Orthokeratology Induced Treatment Zone Diameter and Pupil Diameter on the Optics of the Cornea
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- Paul Gifford
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A Pilot Study Comparing CRT Orthokeratology Lenses with Two Different Treatment Zone Sizes
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- Maria Liu
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Anatomic Factors Contributed to Choroidal Thickening after Orthokeratology: Evidence from Image Binarization of SD-OCT
-
- Jinyun Jiang
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Atropine Combined with Orthokeratology (ACO) in the Treatment of Myopia: Change of Subfoveal Choroidal Thickness (SFChT)
-
- Wenchen Zhao
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Oral 7【Session Room 1】14-Sep 8:10-9:22
●Multifocal CL
- Chair:
- Padmaja Sankaridurg
- (University of New South Wales)
-
- Pauline Cho
- (The Hong Kong Polytechnic University)
Optical and Neural Contribution in the Peripheral Retina to Myopia Control
-
- Geunyoung Yoon
-
Central and Peripheral Visual Quality and Accommodation with Multifocal Contact Lenses
-
- Linda Lundstrom
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Accommodation Response with Multifocal Contact Lenses in Non-presbyopic Subjects
-
- Martin Loertscher
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The Adaptation and Acceptance of Defocus Incorporated Multiple Segments (DIMS) for Chinese Adolescents
-
- Yiqiu Lu
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Measured and Predicted Axial Elongation in the MiSight Clinical Trial
-
- Paul Chamberlain
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Efficacy of Myopia Control Contact Lenses (BHVI Extended Depth of Focus Contact Lens and MiSight) in a Contralateral Study Design
-
- Padmaja Sankaridurg
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Oral 8【Session Room 1】14-Sep 15:23-17:47
●Pharmacological Approach, Potential Therapies and Others
- Chair:
- Ian Morgan
- (Australian National University)
-
- Zhou Xiangtian
- (Wenzhou Medical University)
Current and Emerging Pharmaceutical Interventions for Myopia
-
- Kritchai Vutipongsatorn
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Myopia Controle for Europeans: Evidence-based Protocol
-
- Caroline C.W. Klaver
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Two-Year Clinical Trial of the Low-concentration Atropine for Myopia Progression (LAMP) Study: 0.05% Atropine Remained the Optimal Concentration for Myopia Control
-
- Jason C.S. Yam
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The Efficacy of 0.01% Atropine Ophthalmic Solution for Controlling the Progression of Childhood Myopia (ATOM-J) - Randomized Controlled Trial
-
- Osamu Hieda
-
Efficacy of Low Dose Atropine in Indian Progressive Myopes
-
- Viswanathan Sivaraman
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The Efficacy and Safety of Topical 0.01% Atropine in Controlling Near-work Induced Transient Myopia
-
- Lei Guo
-
A Gold Standard for Myopia Control Efficacy: Cumulative Absolute Reduction of Axial Elongation (CARE)
-
- Mark Bullimore
-
Consistency of Absolute Myopia Control Treatment Effect Across Age (Or Why Tom Aller Got 80% Treatment Efficacy!)
-
- Noel A. Brennan
-
Temporal Considerations in Myopia Control Efficacy
-
- Jaclyn V. Hernandez
-
7-methylxanthine (7-mx) for Myopia Control - Five-year Data
-
- Klaus Trier
-
MyopiaX: Invisible Myopia Treatment using Visible Light
-
- Hamed Bahmani
-
Results with Snyder- Thompson Posterior Scleral Reinforcement in Progressive, High Myopic Children in Hungary
-
- Noemi Szell
-
Oral 9【Session Room 1】15-Sep 8:05-8:53
●Ocular Biometry
- Chair:
- Christine Wildsoet
- (University of California, Berkeley)
-
- Rigmor Baraas
- (University of South-Eastern Norway)
Change of The Refractive Status after Cycloplegia and Its Related Factors in Children Aged 6-12
-
- Bei Du
-
Mathematical Estimation of Axial Length using Routine Optometric Data in the Absence of Formal Biometry
-
- Nabin Paudel
-
Effect of Chromatic and Monochromatic Aberrations on Detecting the Sign of Defocus in the Periphery
-
- Petros Papadogiannis
-
Salivary Melatonin, Sleep and Activity: Myopes Compared to Non-Myopes
-
- Sarah C. Flanagan
-
Oral 10【Session Room 1】15-Sep 8:53-10:17
●Pathologic Myopia/Ocular Circulation and Eye Shape
- Chair:
- Yasushi Ikuno
- (Ikuno Eye Center)
-
- Yuxin Fang
- (Tokyo Medical and Dental University)
Watching Spatially Filtered Movies That Enhance ON or OFF Stimulation Changes Choroidal Thickness
-
- Frank Schaeffel
-
Choroidal Thickness in Australian Indigenous Children
-
- Scott A. Read
-
Representation of the Fundus Shape using Legendre Polynomial Expansions of RPE Segmentation Data Obtained by the OCT with Auto Alignment Function
-
- Toshifumi Mihashi
-
Projections of Myopia-associated Eye Diseases
-
- Xu Cheng
-
Retinal Complications in High Myopia in Europeans
-
- Annechien E.G. Haarman
-
Comparison of Clinical Features in Highly Myopic Eyes with and without Posterior Staphyloma evaluated with Ultrawide-Field Swept-Source OCT
-
- Takashi Watanabe
-
Long-Term Outcomes and Complications of Foveola-nonpeeling/Fovea-sparing Internal Limiting Membrane Surgery of Myopic Traction Maculopathy
-
- Tzyy-Chang Ho
-
Poster
Rapid fire Presentations
Medical Equipment Exhibition, Book Exhibition